Table 4.
The 60 most up- and down-regulated transcripts in Itk-deficiency after anti-CD3- (1) and anti-CD3/CD28-stimulation (2)
| Probe set | Gene Symbol, Gene Title | Itk-/- vs Wt (1) | t-test | Itk-/- vs Wt (2) | t-test |
| 1457120_at | Itk, IL2-inducible T-cell kinase | -6.96 | 0.007 | -6.63 | 0.009 |
| 1451191_at | Crabp2, cellular retinoic acid binding protein II | -5.31 | 0.013 | -2.79 | 0.054 |
| 1449990_at | Il2///LOC630222, interleukin 2 | -3.89 | 0.002 | -5.17 | 0.030 |
| 1436194_at | Prelid2, PRELI domain containing 2 | -3.54 | 0.036 | -2.42 | 0.077 |
| 1437935_at | 4930486G11Rik, RIKEN cDNA | -3.44 | 0.032 | -3.16 | 0.079 |
| 1439995_at | Nhedc2, Na+/H+ exchanger domain containing 2 | -2.92 | 0.021 | -2.71 | 0.028 |
| 1441971_at | Gene name not assigned for this probe set | -2.91 | 0.050 | -2.88 | 0.082 |
| 1426243_at | Cth, cystathionase | -2.9 | 0.000 | -2.8 | 0.072 |
| 1438380_at | Ddx47, DEAD box polypeptide 47 | -2.69 | 0.002 | 2.03 | 0.300 |
| 1450566_at | Il3, interleukin 3 | -2.68 | 0.031 | -2.81 | 0.005 |
| 1420843_at | Ptprf, protein tyrosine phosphatase, receptor type, | -2.49 | 0.027 | -2.07 | 0.222 |
| 1448788_at | Cd200, Cd200 antigen | -2.47 | 0.014 | -2.43 | 0.011 |
| 1427049_s_at | Smo, smoothened homolog (Drosophila) | -2.46 | 0.000 | -2.45 | 0.015 |
| 1422070_at | Adh4, alcohol dehydrogenase 4 (class II) | -2.33 | 0.015 | -2.26 | 0.157 |
| 1456226_x_at | Ddr1, discoidin domain receptor family, member 1 | -2.29 | 0.014 | -2.91 | 0.038 |
| 1419136_at | Akr1c18, aldo-keto reductase family 1, member C18 | -2.09 | 0.052 | 2.41 | 0.008 |
| 1433571_at | Serinc5, serine incorporator 5 | -2 | 0.011 | -2.05 | 0.125 |
| 1425832_a_at | Cxcr6, chemokine (C-X-C motif) receptor 6 | 5.34 | 0.000 | 3.27 | 0.085 |
| 1437463_x_at | Tgfbi, transforming growth factor, beta induced | 5.36 | 0.045 | 2.4 | 0.012 |
| 1421802_at | Ear1, eosinophil-associated, ribonuclease A family, member 1 | 5.38 | 0.017 | 2.8 | 0.000 |
| 1448620_at | Fcgr3, Fc receptor, IgG, low affinity III | 5.57 | 0.036 | 3.72 | 0.004 |
| 1438855_x_at | Tnfaip2, tumor necrosis factor, alpha-induced protein 2 | 5.6 | 0.0034 | 3.12 | 0.000 |
| 1450009_at | Ltf, lactotransferrin | 5.68 | 0.080 | 2.03 | 0.034 |
| 1416514_a_at | Fscn1, fascin homolog 1 | 5.7 | 0.000 | 3.69 | 0.096 |
| 1451948_at | Gm1409, gene model 1409 | 5.81 | 0.002 | 3.45 | 0.136 |
| 1451675_a_at | Alas2, aminolevulinic acid synthase 2, erythroid | 5.84 | 0.003 | 2.92 | 0.096 |
| 1420330_at | Clec4e, C-type lectin domain family 4, member e | 5.89 | 0.014 | 3.15 | 0.091 |
| 1420699_at | Clec7a, C-type lectin domain family 7, member a | 5.98 | 0.014 | 4.05 | 0.004 |
| 1427747_a_at | Lcn2, lipocalin 2 | 5.98 | 0.056 | 2.23 | 0.011 |
| 1427503_at | AI324046, expressed sequence AI324046 | 6.33 | 0.005 | 3.48 | 0.055 |
| 1419082_at | Serpinb2, serine (or cysteine) peptidase inhibitor, clade B, member 2 | 6.34 | 0.001 | 2.51 | 0.125 |
| 1419627_s_at | Clec4n, C-type lectin domain family 4, member n | 6.36 | 0.021 | 2.6 | 0.0129 |
| 1448213_at | Anxa1, annexin A1 | 6.43 | 0.069 | 3.07 | 0.029 |
| 1419874_x_at | Zbtb16, zinc finger and BTB domain containing 16 | 6.62 | 0.032 | 5.3 | 0.001 |
| 1417898_a_at | Gzma, granzyme A | 6.71 | 0.009 | 5.59 | 0.001 |
| 1419598_at | Ms4a6d, membrane-spanning 4-domains, subfamily A, member 6D | 6.73 | 0.005 | 3.27 | 0.083 |
| 1429889_at | Faim3, Fas apoptotic inhibitory molecule 3 | 6.73 | 0.047 | 3.01 | 0.041 |
| 1415904_at | Lpl, lipoprotein lipase | 6.76 | 0.054 | 4.1 | 0.026 |
| 1449254_at | Spp1, secreted phosphoprotein 1 | 6.8 | 0.028 | 3.79 | 0.020 |
| 1427910_at | Cst6, cystatin E/M | 7.1 | 0.023 | 4.17 | 7.43E-06 |
| 1438553_x_at | Gene name not assigned for this probe set | 7.11 | 0.011 | 4.63 | 0.055 |
| 1434150_a_at | Mettl7a///Ubie, methyltransferase like 7A | 7.14 | 0.000 | 4.04 | 0.185 |
| 1442025_a_at | AI467657, expressed sequence AI467657 | 7.48 | 0.041 | 6.52 | 0.000 |
| 1436778_at | Cybb, cytochrome b-245, beta polypeptide | 7.77 | 0.077 | 4.03 | 0.003 |
| 1439426_x_at | Lyz, lysozyme | 7.78 | 0.006 | 2.98 | 0.011 |
| 1449846_at | Ear2///Ear3, eosinophil-associated, ribonuclease A family, member 2 | 8.62 | 0.008 | 3.54 | 0.031 |
| 1434194_at | Mtap2, microtubule-associated protein 2 | 8.73 | 0.035 | 5.78 | 0.000 |
| 1427866_x_at | Beta globin | 9.29 | 0.001 | 5.44 | 0.074 |
| 1450912_at | Ms4a1, membrane-spanning 4-domains, subfamily A, member 1 | 9.4 | 0.087 | 4.31 | 0.036 |
| 1422873_at | Prg2, proteoglycan 2, bone marrow | 9.81 | 0.028 | 4.19 | 0.026 |
| 1419764_at | Chi3l3, chitinase 3-like 3 | 10.51 | 0.070 | 4.1 | 0.004 |
| 1422411_s_at | Ear1///Ear12///Ear2///Ear3, eosinophil-associated, ribonuclease A family, member 1 | 10.54 | 0.010 | 4.61 | 0.000 |
| 1418722_at | Ngp, neutrophilic granule protein | 11.39 | 0.031 | 3.74 | 0.006 |
| 1450989_at | LOC100047300///Tdgf1, teratocarcinoma-derived growth factor | 11.64 | 0.009 | 2.89 | 0.076 |
| 1419394_s_at | S100a8, S100 calcium binding protein A8 | 12.08 | 0.071 | 4.6 | 0.034 |
| 1425436_x_at | Klra3, killer cell lectin-like receptor, subfamily A, member 3 | 12.34 | 0.002 | 14.75 | 0.000 |
| 1415897_a_at | Mgst1, microsomal glutathione S-transferase 1 | 12.62 | 0.082 | 3.77 | 0.006 |
| 1448756_at | S100a9, S100 calcium binding protein A9 | 12.97 | 0.077 | 5.15 | 0.010 |
| 1426171_x_at | Klra7, killer cell lectin-like receptor, subfamily A, member 7 | 14.08 | 0.027 | 14.02 | 0.015 |
| 1425417_x_at | Klra8, killer cell lectin-like receptor, subfamily A, member 8 | 21.07 | 0.026 | 17.99 | 0.000 |
The down-regulated transcripts are shown with "-"