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Effects of 140-fold β2AR overexpression on ventricular function in Gαq-overexpressing transgenic mice. As shown, isoproterenol-stimulated increases in left ventricular fractional shortening were not observed in Gαq/β2ARM and Gαq mice. (n = 6 each); ∗, P < 0.05 vs. untreated; †, P < 0.05 vs. nontransgenic.
