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. 2009 Jun 1;106(24):9679–9684. doi: 10.1073/pnas.0812083106

Fig. 4.

Fig. 4.

Distinct conformations of thtt amyloids in different brain regions of R6/2 mice show distinct cytotoxicity in neuro2a cells. (A and B) Buffer alone or in vitro thttQ42 amyloids formed in the presence of thtt amyloids from different brain regions of R6/2 or WT mice were introduced into stable thttQ150-GFP neuro2a cells. The number of cells with thttQ150-GFP foci was counted after 15 h of thttQ150-GFP expression and cell differentiation (A), and cell viability was examined after 4 days by MTT assay (B). Tg, WT, CTX, ST, HP, and CBL denote R6/2 mice, wild-type mice, cerebral cortex, striatum, hippocampus, and cerebellum, respectively.*, P < 0.05. Values are mean ± SD. (C) A proposed mechanism of conformation-dependent cytotoxicity of thtt amyloid.