Figure 5. Time domains for AIH-induced phrenic (top) and XII LTF (bottom) and the effects of pre-treatment with apocynin (600 μm) or DPI (1 mm).

AIH caused a progressive increase in nerve amplitude (i.e. LTF) in phrenic and XII nerves, which was attenuated or blocked by DPI and apocynin, respectively. Note that AIH-induced XII LTF was not affected by intrathecal DPI or apocynin. Values are averaged for each treatment group for 15, 30 and 60 min post-AIH. Values are means ± 1 s.e.m. † indicates significant difference from baseline value; ‡ significant difference from time control (TC) value at the same time point.