Table 2.
Effect of 20 μm ZD7288 on membrane parameters of CS neurons
| Parameter | Control | ZD7288 (20 μm) | n | P |
|---|---|---|---|---|
| Input resistance (MΩ) | 424 ± 79 | 657 ± 102 | 15 | 0.0001 |
| Resting potential (mV) | −60.0 ± 1.7 | −64.9 ± 2.1 | 15 | 0.0009 |
| Rheobase current (pA pF−1) | 10.8 ± 5.3 | 12.8 ± 6.6 | 6 | 0.6 |
| AP half-width (ms) | 0.82 ± 0.17 | 0.88 ± 0.06 | 5 | 0.003 |
| AP peak amplitude (mV) | 90 ± 6.3 | 81 ± 5.1 | 5 | 0.01 |
Input resistance was calculated from the peak voltage response to a hyperpolarizing current pulse. Rheobase current was measured by injection of a 1 nA s−1 current ramp. Action potential (AP) properties were measured after brief (5 ms) current injections. P is the result of a paired t test.