Table I.
Adjuvant | Type | Cell-mediated immunity (Th1) | Humoral immunity (Th2) | Receptor |
---|---|---|---|---|
Cholera toxin | Exotoxin | +a | +++ | GM1 ganglioside |
lpxL1 LPS | Endotoxin | ++ | ++ | TLR4 |
Quil A | Saponin based | +++ | ++ | Not identified |
CpG | Bacterial DNA | ++++ | + | TLR9 |
Alum | Inorganic salt | + | +++ | Not identified |
aHumoral and cellular immunity in arbitrary units represent the ability of adjuvants to enhance Th2 response or CTL or Th1, respectively, to foreign antigens