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. Author manuscript; available in PMC: 2009 Jun 2.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Mar 25;325(3):751–757. doi: 10.1124/jpet.108.136374

Figure 9.

Figure 9

The figure shows a putative scheme for the possible pathways studies in the present study. Activation of TRPV1 causes the release of the neuropeptides, including CGRP and SP. SP subsequently activates NK1 receptors located in sensory nerves and evokes ARNA. In contrast, CGRP-induced increases in ARNA depend on TRPV1 activation. It is unknown whether all the components are expressed in the same cell, and the scheme is a simplified version that intends to depict possible crosstalk between TRPV1, CGRP and NK1 receptors.