Table 1.

Factors that regulate LES function

Factors that increase tLESRs	Factors that decrease tLESRs
Gastric distention	GABA agonists
Pharyngeal stimulation	Anticholinergics
High-fat meals	Opioid receptor agonists
CCK-A receptor agonists	Nitric oxide synthase inhibitors
	Endoscopic therapy
	Fundoplication