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. 2009 Mar 27;8(3):28. doi: 10.1186/jbiol128

Table 1.

The 27 genes included in the two signatures

Gene symbol Gene name Hu et al. [3] Tutt et al. [4] Basal* 16-kinases GGI
ADM Adrenomedullin Yes Up
ANGPTL4 Angiopoietin-like 4 Yes
C14orf58 Chromosome 14 open reading frame 58 Yes Up
DDIT4 DNA-damage-inducible transcript 4 Yes Up
FABP5 Fatty acid binding protein 5 (psoriasis-associated) Yes Up
GAL Galanin Yes Up
NDRG1 N-myc downstream regulated gene 1 Yes Up
NP Nucleoside phosphorylase Yes Up
PLOD1 Procollagen-lysine 1,2-oxoglutarate 5-dioxygenase 1 Yes Up
RRAGD Ras-related GTP binding D Yes Up
SLC16A3 Solute carrier family 16 (monocarboxylic acid transporters), member 3 Yes
UCHL1 Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) Yes Up
VEGF Vascular endothelial growth factor Yes Up
BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) Yes Up Yes Yes
CCNB1 Cyclin B1 Yes Up Yes
CENPA Centromere protein A, 17 kDa Yes Up Yes
DC13 DC13 protein Yes Yes
DIAPH3 Diaphanous homolog 3 (Drosophila) Yes
MELK Maternal embryonic leucine zipper kinase Yes Up Yes
MYBL2 v-Myb myeloblastosis viral oncogene homolog (avian)-like 2 Yes Up Yes
ORC6L Origin recognition complex, subunit 6 like (yeast) Yes Up
PKMYT1 Protein kinase, membrane associated tyrosine/threonine 1 Yes Up
PRR11 Proline rich 11 Yes
RACGAP1 Rac GTPase activating protein 1 Yes
RFC4 Replication factor C (activator 1) 4, 37 kDa Yes Up
TK1 Thymidine kinase 1, soluble Yes
UBE2S Ubiquitin-conjugating enzyme E2S Yes Up

*Genes upregulated in basal versus luminal A tumors [5]; 16-kinase signature [8]; genomic grade index [7].