Table 1.
The frequencies of estimated 6-SNP haplotypes† for the 9p21.3 T2D locus in seven different geographic regions
| rs2383208 | rs7045889 | rs10811659 | rs10757282 | rs10811661 | rs10757283 | Africa N = 102 | Middle East N = 160 | Europe N = 156 | C.S. Asia N = 200 | E. Asia N = 229 | Oceania N = 28 | America N = 63 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G | A | A | G | C | T | 0.029 | 0.197 | 0.157 | 0.125 | 0.393 | 0.446 | 0.167 |
| A | A | A | G | T* | T* | 0.118 | 0.187 | 0.266 | 0.221 | 0.215 | 0.196 | 0.206 |
| G | G | A | A | T* | T* | 0.131 | 0.022 | NF | NF | NF | NF | NF |
| A | A | A | A | T* | T* | 0.182 | NF | NF | NF | NF | NF | NF |
| G | A | A | A | T* | T* | 0.052 | NF | NF | NF | NF | NF | NF |
| A | G | A | A | T | C | 0.302 | 0.334 | 0.308 | 0.418 | 0.244 | 0.089 | 0.547 |
| A | A | G | A | T | C | 0.022 | 0.177 | 0.198 | 0.199 | 0.091 | 0.161 | NF |
| A | G | G | A | T | C | 0.051 | 0.038 | 0.046 | 0.018 | 0.011 | 0.071 | 0.024 |
| G | G | A | A | T | C | 0.042 | 0.015 | NF | NF | NF | NF | NF |
| A | A | A | A | T | C | 0.053 | NF | NF | NF | NF | NF | 0.024 |
The TT haplotype of SNPs rs10811661 and rs10757283 is the T2D risk haplotype and is in bold-face and marked with an asterisk, while the protective haplotype (GAAGCT) is in bold-face and italicized. †Population-specific haplotypes <5% frequent were omitted. NF, haplotype not found in given geographic region.