Table 2.
The frequencies of estimated haplotypes† for eight CHD-associated SNPs in seven different geographic regions
| rs10116277 | rs1537370 | rs10738607 | rs4977574 | rs944797 | rs2383207 | rs1537375 | rs1333049 | Africa N = 102 | Middle East N = 160 | Europe N = 156 | C.S. Asia N = 200 | E. Asia N = 229 | Oceania N = 28 | America N = 63 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G | C | T | A | A | A | T | G | NF | 0.209 | 0.384 | 0.327 | 0.328 | 0.554 | 0.449 |
| T | T | C | G* | G* | G* | C* | C | 0.115 | 0.516 | 0.536 | 0.478 | 0.470 | 0.161 | 0.302 |
| T | T | C | G* | G* | G* | C* | G | NF | 0.100 | 0.031 | 0.029 | NF | 0.143 | NF |
| G | C | C | G* | G* | G* | C* | C | NF | 0.021 | 0.017 | NF | 0.019 | NF | 0.032 |
| T | T | C | A | G | G | C | G | 0.021 | 0.019 | NF | NF | NF | NF | NF |
| T | T | T | A | A | G | C | G | 0.345 | 0.041 | NF | NF | NF | 0.054 | NF |
| T | C | T | A | A | G | C | G | 0.246 | 0.013 | NF | NF | NF | NF | 0.016 |
| T | T | C | A | A | G | C | G | NF | NF | NF | 0,035 | 0.092 | 0.054 | NF |
| T | T | T | A | G | G | T | G | 0.129 | 0.031 | NF | 0,027 | NF | NF | NF |
| G | C | T | A | G | G | C | C | NF | NF | NF | NF | NF | NF | 0.147 |
| G | C | T | A | A | G | C | G | 0.027 | NF | NF | NF | NF | 0.036 | NF |
| T | T | T | A | A | A | T | G | NF | 0.019 | NF | 0,015 | 0.039 | NF | 0.012 |
| G | C | T | A | A | A | T | C | NF | NF | NF | 0,013 | NF | NF | 0.016 |
The risk alleles in Europeans are in bold-face and italicized, and the core risk haplotype is marked with an asterisk. †Population-specific haplotypes <5% frequent were omitted. NF, haplotype not found in given geographic region.