Table 2.

Constituents of commercially available PCCs in Europe (based on product labeling*)

	Factor content								Antithrombotic content
	II		VII		IX		X		Protein C, S, Z (label IU/ml)
Product (manufacturer); international availability	Label IU/ml	Ratio	Label IU/ml	Ratio	Label IU/ml	Ratio	Label IU/ml	Ratio	C	S	Z	ATIII (label IU/ml)	Heparin (label IU/ml)
Beriplex P/N (CSL Behring); major western European countries	20–48	133%	10–25	69%	20–31	100%	22–60	161%	15–45	13–26	Not in label	0.2–1.5	0.4–2.0
Octaplex (Octapharma); major western European countries	11–38	98%	9–24	66%	25	100%	18–30	96%	7–31	7–32	Not in label	Not in label	Not in label
Prothromplex Total/S-TIM 4 Immuno (Baxter); Sweden, Germany, Austria	30	100%	25	83%	30	100%	30	100%	>20	Not in label	Not in label	0.75–1.5	<15
Prothromplex TIM 3 (Baxter); Italy, Austria	25	100%	Not in label	-	25	100%	25	100%	Not in label	Not in label	Not in label	Not in label	3.75
Cofact/PPSB SD (Sanquin/CAF); Netherlands, Belgium, Austria, Germany	≥ 15	75%	≥ 5	25%	≥ 20	100%	≥ 15	75%	Not in label	Not in label	Not in label	Present, not quantified	Not in label
Kaskadil (LFB); France	40	160%	25	100%	25	100%	40	160%	Not in label	Not in label	Not in label	Not in label	Present, not quantified
Uman Complex DI (Kedrion); Italy	25	100%	Not in label	0%	25	100%	20	80%	Not in label	Not in label	Not in label	Present, not quantified	Present, not quantified
PPSB-human SD/Nano (Octapharma); Germany	25–55	130%	7.5–20	45%	24–37.5	100%	25–55	130%	20–50	5–25	Not in label	0.5–3	0.5–6

Factor content ratios are based on the content of factor IX [27]. *In Europe, ranges are usually given on the product label, in accordance with the European Pharmacopoeia; single values are generally from older, national registrations. ATIII, antithrombin III; PCC, prothrombin complex concentrate. Reproduced from Levy et al. Perioperative hemostatic management of patients treated with vitamin K antagonists [27]. Reproduced with permission from Lippincott Williams & Wilkins (http://www.lww.com/)