Table 4.
Time course to endpoints other than procalcitonin in bacterial sepsis patients according to antibiotic therapy
| First-line empirical antibiotic therapy | P value | ||
| Appropriate | Inappropriate | ||
| D1 | |||
| SOFA score (points) | 6.2 (3.5) | 6.4 (4.0) | 0.77 |
| Mean arterial pressure (mmHg) | 74.2 (18.7) | 71.3 (21.3) | 0.41 |
| Platelet count (giga/l) | 201.4 (123.0) | 231.4 (175.2) | 0.23 |
| Creatininemia (μmol/l) | 197.7 (184.2) | 203.6 (173.5) | 0.85 |
| Lactate (mmol/l) | 3.4 (3.2) | 2.8 (1.8) | 0.26 |
| PO2/FiO2 (mmHg) | 229 (129) | 280 (163) | 0.05 |
| C-reactive protein (mg/l) | 159.9 (112.9) | 121.1 (105.0) | 0.11 |
| D2 | |||
| SOFA score (points) | 6.0 (3.8) | 6.1 (4.3) | 0.89 |
| Mean arterial pressure (mmHg) | 78.6 (18.6) | 76.2 (18.7) | 0.48 |
| Platelet count (giga/l) | 193.0 (128.9) | 194.8 (159.9) | 0.94 |
| Creatininemia (μmol/l) | 183.9 (175.7) | 206.0 (185.5) | 0.49 |
| Lactate (mmol/l) | 2.8 (2.8) | 2.1 (0.8) | 0.15 |
| PO2/FiO2 (mmHg) | 252 (132) | 251 (129) | 0.96 |
| C-reactive protein (mg/l) | 171.7 (101.8) | 159.3 (86.6) | 0.59 |
| D3 | |||
| SOFA score (points) | 5.5 (4.0) | 5.7 (4.2) | 0.73 |
| Mean arterial pressure (mmHg) | 82.3 (19.1) | 78.2 (22.3) | 0.26 |
| Platelet count (giga/l) | 192.1 (127.6) | 177.6 (144.2) | 0.55 |
| Creatininemia (μmol/l) | 173.0 (151.9) | 199.9 (189.3) | 0.35 |
| Lactate (mmol/l) | 2.4 (2.8) | 1.8 (0.7) | 0.24 |
| PO2/FiO2 (mmHg) | 263 (120.7) | 275 (108.6) | 0.61 |
| C-reactive protein (mg/l) | 176.4 (116.4) | 160.0 (86.1) | 0.53 |
| D4 | |||
| SOFA score (points) | 4.5 (3.8) | 5.8 (3.9) | 0.24 |
| Mean arterial pressure (mmHg) | 81.1 (26.8) | 77.0 (14.1) | 0.53 |
| Platelet count (giga/l) | 189.8 (139.3) | 135.8 (122.9) | 0.14 |
| Creatininemia (μmol/l) | 181.1 (161.4) | 216.6 (166.7) | 0.39 |
| Lactate (mmol/l) | 2.6 (3.5) | 1.5 (0.5) | 0.09 |
| PO2/FiO2 (mmHg) | 249 (122.5) | 276 (79) | 0.36 |
| C-reactive protein (mg/l) | 139.8 (103.7) | 122.2 (74.5) | 0.48 |
Time course of relevant endpoints other than procalcitonin in patients with bacterial sepsis according to appropriateness of first-line empirical antibiotic therapy. SOFA, Sepsis-related Organ Failure Assessment; D1, day sepsis is diagnosed.