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(A) Sequence-specific inhibition of IL-6 protein production determined by ELISA after pressure-mediated transfection of cultured human saphenous vein at 300 mmHg for 10 min with either sequence A or sequence B ODN (n = 4). (B) IL-6 mRNA measured by quantitative RT-PCR. One vein segment from each of three patients was either left untreated (U) or was treated with antisense (AS) or reverse antisense (RAS) ODN of IL-6 sequence A or sequence B (see text for details).
