. Author manuscript; available in PMC: 2009 Jun 2.

Published in final edited form as: Psychopharmacology (Berl). 2007 Jul 10;194(4):505–515. doi: 10.1007/s00213-007-0861-5

Table 2.

Effect of rimonabant or placebo on heart rate and subjective responses to a smoked cannabis cigarette (2.78% THC) in 34 adult male cannabis users

		Day 8		Day 15
		Placebo^a (daily)	40 mg^b (daily)	Placebo^b (daily)	90 mg^b (day 15 only)	40 mg^b (daily)
Heart rate increase (bpm)	Mean	47.8^c	12.2	38.4	13.7	13.2
	Median	49.4	10.6	37.4	11.8	14.4
	Range	15.4−95.2	2−19.8	18−74.2	−1.6−33.2	0.4−31.2
	95% CI	37.7−57.9	9.1−15.3	29.1−47.8	6.8−20.6	7.9−18.6
T_max (min)	Mean change	16.3^c	22.5	16.2	26.4	22.4
	Median	9.0	14.0	7.3	34.0	34.0
	Range	2−54	3−65	4−35	1−67	1−35
	95% CI	10.6−21.7	11.2−33.7	7.6−24.8	14.5−38.2	13.2−31.6
AUC_{0−55 min}	Mean Change	31.6^c	2.8	25.3	4.4	4.1
	Median	29.4	2.5	22.5	3.4	2.5
	Range	6.3−74.2	−2.6−10.9	7.5−52.3	−7.5−16.7	−4.1−13.5
	95% CI	23.6−39.7	0.6−5.1	17.7−32.9	−.0.4−9.3	0.5−7.7
VAS (mm) composite	Mean Peak	80.0	64.6	69.8	49.3	59.8
	Median	79.0	64.7	76.7	76.7	65.3
	Range	48−100	31.3−98	4.7−100	3.3−84.7	4.7−96.7
	95% CI	72.9−87.0	54.1−75.1	51.1−88.4	27.7−70.9	43.9−75.8
T_max (min)	Mean	18.1	25.3	19.7	17.5	14.0
	Median	13.5	23.7	24	17	12
	Range	7−60	7−59	6−30.2	6−28	7−23
	95% CI	12.9−23.2	17.4−33.1	13.5−25.9	13.4−21.7	10.2−17.9
AUC_{0−55 min}	Mean	66.3	53.2	60.3	40.7	38.1
	Median	66.5	48.2	53.2	61.4	41.8
	Range	28−99.9	13.7−96.5	2.9−97.8	0.6−79.2	0.6−88.4
	95% CI	56.2−76.3	40.5−66.0	41.0−79.6	20.1−61.3	22.6−53.5
M-scale	Mean Peak	8.1	5.5	6.5	5.0	5.0
	Median	8.5	6	6	5	4
	Range	2−12	2−11	1−12	0−12	0−11
	95% CI	6.8−9.4	4.0−7.1	4.2−8.9	2.7−7.3	2.6−7.4
T_max (min)	Mean	23.8	19.9	19.3	13.9	14.5
	Median	22.0	10	22	8	12
	Range	8−65	8−62	7−31	7−28	7−28
	95% CI	16.5−31.2	7.6−32.3	14.1−24.5	9.4−18.4	9.8−19.2
AUC_{0−55 min}	Mean	6.1	3.6	5.5	3.7	3.7
	Median	6.5	4.3	3.9	3.0	1.7
	Range	1.1−10.7	0.3−7.6	0.2−11.9	0−11.8	0−10.2
	95% CI	4.8−7.5	2.3−5.0	3.1−7.9	1.5−5.9	1.3−6.1

Heart rate Change from baseline (before oral rimonabant dosing); VAS composite mean of scores on three 100-mm visual analog scales for “How high do you feel now?”, “How strong is the drug effect you feel now?” and “How stoned on marijuana are you now?” Maximum possible score=100; M-scale marijuana subscale of Addiction Research Center Inventory. Maximum possible score=12; T_max time during session that maximum value of variable was reached

n=22

n=11

n=23