. Author manuscript; available in PMC: 2009 Jun 2.

Published in final edited form as: Psychopharmacology (Berl). 2007 Jul 10;194(4):505–515. doi: 10.1007/s00213-007-0861-5

Table 3.

Percent blockade (95% confidence interval) of peak cannabis effect by oral rimonabant in 22 adult male subjects who smoked an active cannabis (2.78% THC) cigarette on day 8 or 15 (n = 11 for each dose group)

Pharmacodynamic measure	Day 15		Day 8
	40 mg daily for 15 days	90 mg (day 15 only)	40 mg daily for 8 days
ΔHeart rate	65.6 (36.3, 100)	64.3 (35.1, 98.9)	75.7 (35.7, 124)
VAS composite	14.3 (−26.3, 57.3)	29.4 (−10.6, 74.4)	19.2 (3.1, 35.7)
M-scale	23.6 (−30.8, 85.8)	23.6 (−30.8, 85.8)	30.3 (2.2, 60.0)

ΔHeart Rate Change from baseline (before rimonabant dosing); VAS composite mean of scores on three 100-mm visual analog scales for "How high do you feel now?", "How strong is the drug effect you feel now?" and "How stoned on marijuana are you now?"; M-scale marijuana subscale of Addiction Research Center Inventory