. Author manuscript; available in PMC: 2009 Jun 2.

Published in final edited form as: Psychopharmacology (Berl). 2007 Jul 10;194(4):505–515. doi: 10.1007/s00213-007-0861-5

Table 4.

Pharmacokinetic parameters for Δ9-tetrahydrocarmabinol (THC) in 36 adult males after smoking one cannabis cigarette (2.78% THC) on day 8 and on day 15

Parameter	Day 8		Day 15
	40 mg^a	Placebo^b	40 mg^a	90 mg^a	Placebo^c
C_max (μg/l)
Mean	162.5	204.8	166.0	179.8	129.4
Median	183.9	191.2	160.9	155.3	119.7
Range	11.3−372.9	58.6−414.1	23.8−306.5	89.0−360.0	56.9−222.2
95% CI	105.7−219.3	166.7−242.8	113.9−218.2	129.4−230.3	97.6−161.1
T_max (min)
Mean	8.0	7.6	8.0	7.5	7.8
Median	7.8	7.8	7.8	7.8	7.8
Range	7.8−10.2	3.0−10.2	7.8−10.2	1.8−10.2	7.8
95% Cl	7.6−8.5	7.1−8.1	7.6−8.5	6.3−8.6	NA
AUC_0−1.25 (μg·h/l)
Mean	44.5	62.6^d	48.3	44.5	37.7^e
Median	44.5	55.3	46.8	47.6	32.3
Range	4.7−99.4	19.0−108.4	8.4−94.9	21.9−77.9	14.5−64.5
95% CI	30.4−58.7	50.1 −75.2	32.5−64.2	35.6−54.1	26.7−48.7

n=11

n=22

n=10

n=21

n=9