Table 5.

Pharmacokinetic parameters for 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in 36 adult males after smoking one cannabis cigarette (2.78% THC) on day 8 and on day 15

Parameter	Day 8		Day 15
	40 mga	Placebob	40 mga	90 mga	Placeboc
Cmax (μg/l)
Mean	28.2	30.9	33.4	37.1	23.2
Median	25.2	30.4	30.0	32.7	22.2
Range	4.7−50.4	12.4−51.8	6.1−71.0	20.9−66.1	10.6−44.9
95% CI	20.7−35.8	25.5−36.3	21.8−45.1	27.3−46.9	16.8−29.5
Tmax (min)
Mean	22.0	21.2	24.3	19.7	20.3
Median	22.8	19.0	22.8	18.0	18.0
Range	18.0−24.0	13.2−28.2	18.0−58.2	12.0−28.2	18.0−22.8
95% CI	20.8−23.2	19.1−23.3	17.4−31.3	17.2 −22.2	18.5−21.7
AUC0−1.25 (μg·h/l)
Mean	27.2	31.0	31.6	34.1	22.0d
Median	24.4	27.6	27.3	29.9	19.5
Range	5.1−48.9	12.5−55.5	5.6−71.0	21.1−60.0	10.9−42.1
95% CI	20.2−34.1	25.3−36.7	20.6−42.6	25.5−42.7	15.6−28.4

^an=11

^bn=17

^cn=10

^dn=9