Table 6.

Pharmacokinetic parameters for rimonabant in adult men receiving 40 mg daily for 15 days (n=12) or 90 mg once (n=12)

Parameter	Day 8	Day 15
	40 mg	40 mg	90 mg
Cmax (μg/l)
Mean	307.8	334.6	478.6
Median	240.0	294.5	431.5
Range	157.0−576.0	185.0−705.0	90.2−958.0
95% CI	221.6−393.9	246.3−422.9	291.4−665.8
Tmax (h)
Mean	1.77	2.35	3.05
Median	1.75	2.39	2.13
Range	0.82−3.25	1.00−4.00	1.00−8.00
95% Cl	1.38−2.17	1.78−2.92	1.67−4.43
AUC0−24 (μg·h/l)
Mean	3341.4	3681.7a	3260.1a
Median	2860.6	3201.4	2722.8
Range	1145.3−6536.6	1394.4−8362.8	1151.1−7582.6
95% CI	2387.1−4295.6	2488.7−4874.6	2123.0−4397.3
AUC2−3.25 (μg·h/l)
Mean	307.2	335.6	416.3
Median	236.9	285.3	403.8
Range	104.7−598.9	190.2−692.0	72.4−1113.4
95% CI	210.7−403.7	246.6−425.0	233.3−599.4

^an=11