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. 2008 Sep 4;68(7):1220–1227. doi: 10.1136/ard.2008.091876

Figure 1.

Figure 1

(A) Median change in synovial expression of cellular infiltrate after 4 months of treatment with abatacept. Multiple synovial biopsies were obtained from representative inflamed sites and stained with antibodies to a range of synovial markers. Synovial lining layer (LL) and sub-lining layer (SL) expression of each marker was scored semi-quantitatively on a five-point scale (0, minimal infiltration; 4, maximal infilatration) and a median percentage change from baseline calculated. *p<0.05. Error bars represent 25th and 75th percentiles; the number of patients analysed was 11 in all cases. (B) Example of CD68 expression in paired synovial tissue samples from a patient with rheumatoid arthritis treated with abatacept. Panels I and II are the negative controls for the patient at baseline and post-abatacept, respectively. Panels III and IV demonstrate macrophage (CD68) staining at baseline and post-abatacept, respectively. Considerable LL and SL CD68 expression is observed in the baseline biopsy; expression continues to be marked post-abatacept. ICAM-1, intercellular adhesion molecule type 1.