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. Author manuscript; available in PMC: 2009 Jun 2.
Published in final edited form as: J Neuroimmune Pharmacol. 2007 Oct 25;3(1):26–34. doi: 10.1007/s11481-007-9083-1

Fig. 1.

Fig. 1

Effects of CXCL12 and DAMGO on [35S]GTPγS incorporation in brain homogenates from pups and adult rats. Brain cortices of P2–P7 pups (a) or adult animals (b) were exposed to CXCL12 or DAMGO as indicated. Graphs represent the mean ratio of agonist-stimulated GTP binding over basal (n=3) ± SEM. *p<0.01 and **p<0.05 versus basal; Dunnett's multiple comparison test after ANOVA. The bottom panel (c) shows data from adult hippocampus homogenates treated with different concentrations of CXCL12. DAMGO or morphine was used as positive controls (inset), as no response to CXCL12 was observed. p<0.01, morphine 1, 0.1, 0.001 μM versus basal; p<0.05, morphine 0.3, 0.03, 0.003 μM versus basal; p<0.05, DAMGO 10 and 1 μM versus basal; Dunnett's multiple comparison test after ANOVA