Table 3.

Adjusted responses of heart rate and systolic blood pressure to cold pressor testing

	Parameter	Coefficient	95% confidence interval	P-value
Heart rate response	Male sex	−0.8	−6.2 to 4.5	0.75
	Black ethnicity	1.3	−5.4 to 8.0	0.70
	Age	0.1	−0.4 to 0.5	0.83
	Body Mass Index	−0.3	−1.0 to 0.4	0.40
	Positive FH of hypertension	−1.0	−6.0 to 4.1	0.70
	Baseline heart rate	−0.1	−0.4 to 0.1	0.29
	ADRA2C del/del genotype	15.8	8.0 to 23.7	<0.001
	GNB3 T/T genotype	6.8	0.9 to 12.7	0.026
Systolic blood pressure response	Male sex	2.7	−4.5 to 10.0	0.45
	Black ethnicity	−0.7	−8.8 to 7.5	0.87
	Age	0.5	0.0 to 1.1	0.065
	Body Mass Index	−0.3	−1.1 to 0.5	0.46
	Positive FH of hypertension	1.8	−4.1 to 7.7	0.55
	Baseline systolic blood pressure	0	−0.4 to 0.4	0.85
	ADRA2C del/del genotype	9.1	0.0 to 18.2	0.051
	GNB3 T/T genotype	5.7	−1.2 to 12.7	0.10

Listed are covariates and multiple linear regression coefficients, their confidence intervals, and P-values for two response variables (changes from baseline in heart rate and systolic blood pressure). FH=family history; ADRA2C del/del genotype=homozygous ADRA2C 322-325 deletion genotype (coded as 1) compared to Ins/Ins and Ins/del genotype combined (coded as 0); GNB3 T/T genotype=homozygous GNB3 825 T/T genotype (coded as 1), compared to C/C and C/T combined (coded as 0). Sex and ethnicity were coded as 0/1 for female/male and white/black, respectively, so that the correlation coefficients reflect sex and ethnic differences, respectively.