Table 4. Adjuvant treatment with interferon alpha: therapeutic schemes (8).

Scheme	Dosage	Indication
Low-dose interferon alpha-2	3m IU s.c. 3×/week over 18–24 months	Stages II/III
High-dose interferon alpha-2b
Initial treatment	20m IU/m2 i.v., days 1–5 over 4 weeks	Stage III
Maintenance treatment	10m IU/m2 s.c., 3×/week over 11 months
Pegylated interferon alpha-2b
Initial treatment	6 µg/kg/week over 8 weeks	Stage III
Maintenance treatment	3 µg/kg/week up to the end of 5 years