Table I.

Examples of differential regulation of protein spots

-Fold change values were calculated from the mean values of the normalized and standardized spot volumes of each group (G2, G2, and bronchial epithelium). Proteins listed were shown to be differentially regulated in lung SCC (G2 and G3 grade) as compared with normal bronchial epithelium. The -fold change values and t test results for individual comparisons (G2/bronchus, G3/bronchus, G2 and G3/bronchus, and G2/G3) are provided as well as the human International Protein Index accession numbers and the GenBank™ names of the proteins. A complete list of identified proteins and potentially co-migrating proteins can be found in supplemental Table 3.

Spot no.	Protein	Accession no.	G2/bronchus		G3/bronchus		G2 and G3/bronchus		G2/G3
			-Fold change	t test < 0.05	-Fold change	t test < 0.05	-Fold change	t test < 0.05	-Fold change	t test < 0.05
865	KRT6A; keratin, type II cytoskeletal 6a	IPI00300725.7	12.5	Yes	2.9	Yes	7.7	Yes	−4.3	Yes
954	KRT6A; keratin, type II cytoskeletal 6a	IPI00300725.7	5.6	Yes	2.1	No	3.9	Yes	−2.6	No
1006	KRT17; KRT17 protein	IPI00747707.1	7.9	Yes	2.1	No	5.0	No	−3.8	No
1025	KRT17; keratin, type I cytoskeletal 17	IPI00450768.7	19.5	Yes	7.5	Yes	13.5	Yes	−2.6	No
1039	KRT17; KRT17 protein	IPI00747707.1	33.5	Yes	1.7	No	17.6	No	−19.2	Yes
1201	SERPINH1; serpin H1 precursor	IPI00032140.4	9.0	Yes	7.7	Yes	8.4	Yes	−1.2	No
1621	KRT16; keratin, type I cytoskeletal 16	IPI00217963.3	16.9	Yes	13.2	Yes	15.0	Yes	−1.3	No