Fig. 3.

Spread in ΔS of regulated pathways in response to high LET IR versus low LET IR in U-1810 cells. Using the data from Table I, the numbers of differentially regulated pathways from high versus low LET-irradiated cells are plotted against their corresponding ΔS. Each dot in the graph represents a specific ΔS, and when ΔS approaches zero several pathways share the same ΔS, and therefore a dot could represent one or several pathways (see Table I). One procedure to identify significantly (de)activated pathways was to find the pathways that have a delta score that is so large that it is considered an outlier in the data set in point. Pathways are considered as outliers if the pathway has a delta score >|3σ|, which in the exemplified data set corresponds only to the JNK pathway (delta score, 24,897).