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Effects of AGEs on islet function in vitro. Freshly isolated islets from normal C57/BL6 mice were cultured in the presence of BSA or AGE-BSA for 48 h. Islets were then stimulated with 1.7 or 16.7 mm glucose for 1 h. Media were then collected for use in an insulin secretion assay (A), and the islets were collected to measure insulin content (B). Data are presented as means ± sem of three independent experiments. *, P < 0.05 compared with the controls.
