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. 2009 Mar 5;150(6):2948–2956. doi: 10.1210/en.2008-1690

Figure 6.

Figure 6

Schematic relationship between intrathymic expression of the endogenous TSHR or the transgenic human TSHR A subunit and induced TSHR antibody responses in mice that are deficient or sufficient for Aire. A, TBI levels after the second immunization in Aire +/+ and Aire −/− mice that are nontransgenic or transgenic mice that express low (Lo) or high (Hi) intrathyroidal levels of the human A subunit. B, Intrathymic expression of the mTSHR and human A subunit in mouse strains indicated in A.