Relative renal expression of genes involved in phosphate homeostasis. A, Slc34a1, sodium-phosphate cotransporter IIa. B, Slc34a3, sodium-phosphate cotransporter IIc. C, Cyp24a1, 24-hyroxylase. D, Cyp27b1, 1-α-hydroxylase. E, Kl. The data are presented as mean fold change ± sem (n = 10–12 animals per group). White bar, wild-type; gray bar, heterozygote; black bar, homozygote. *, P < 0.05 and **, P < 0.01 vs. wild-type control mice of the same age.