Table 2.
Micro-CT measurements of male femurs
| +/+ | −/− | |
|---|---|---|
| Three-dimensional trabecular analyses | ||
| Tissue volume (mm3) | 1.77 ± 0.05 | 2.14 ± 0.06a |
| Bone volume (mm3) | 0.22 ± 0.02 | 0.37 ± 0.04b |
| Percent bone volume (%) | 12.38 ± 1.25 | 17.51 ± 1.65 |
| Tissue surface (mm2) | 9.62 ± 0.15 | 10.84 ± 0.27b |
| Bone surface (mm2) | 16.31 ± 1.65 | 22.86 ± 0.83b |
| Trabecular pattern factor (1/mm) | 21.22 ± 1.06 | 14.89 ± 2.19 |
| Tb.Th (mm) | 0.051 ± 0.002 | 0.061 ± 0.006 |
| Tb.N (1/mm) | 2.48 ± 0.34 | 2.89 ± 0.07 |
| Apparent density (bone plus marrow) (pixel intensity) | 38.40 ± 1.77 | 46.09 ± 2.30 |
| Bone density (mineralization) (pixel intensity) | 119.14 ± 1.04 | 126.01 ± 3.17 |
| Two-dimensional cortical analyses | ||
| BA (mm2) | 0.86 ± 0.02 | 1.06 ± 0.05b |
| Bone perimeter (mm) | 9.87 ± 0.28 | 11.39 ± 0.82 |
| Polar moment of inertia (mm4) | 0.46 ± 0.03 | 0.69 ± 0.07b |
| Bone density (mineralization) (pixel intensity) | 175.95 ± 1.24 | 176.29 ± 0.99 |
The data are presented as mean ± sem (number of animals: three males per group).
a
P < 0.01 (vs. wild-type control mice).
b
P < 0.05 (vs. wild-type control mice).