Figure 6.

BPA inhibits the genes most significantly regulated by T₃. A, The expression of most of the top 50 significantly T₃-up-regulated genes in the intestine is reduced by BPA. The genes in shade are attenuated by BPA. B, Most of the top 50 significantly T₃-down-regulated genes in the intestine have their T₃-dependent repression reduced by the presence of BPA. The genes in shade are abrogated by BPA. *, The gene is also significantly regulated by T₃ in the tail (t), limb (l), and brain (b), respectively. NP, Gene not present in the earlier cDNA array used for the analysis of the organs t, l, and b (64). Blanks under the other organs indicate genes are not significantly regulated by T₃ in t, l, and b.