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. 2009 Feb 25;296(5):R1606–R1612. doi: 10.1152/ajpregu.90878.2008

Fig. 4.

Fig. 4.

THIP inhibits light-induced period mRNA expression during the subjective night. A: representative autoradiograms. Per1 and Per2 mRNA increases induced by light in the early night (CT 13.5; A) were abolished in animals pretreated with THIP (B). Arrows indicate the SCN. B: THIP (22 nmol) delivered to the SCN region just prior to a light pulse during the early night (CT 13.5) and late night (CT 20) inhibited light-induced increases in Per1 mRNA. THIP delivered to the SCN region just prior to a light pulse during the early subjective night (CT 13.5) also inhibited light-induced increases in Per2 mRNA. The effect of light in saline-treated animals for Per1 at both time points and Per2 in the early night was significantly greater than all other groups. There were no significant differences between any of the Per2 mRNA groups in the late night. Bars represent means ± SE; *P < 0.05.