Table 1.
Arterial blood pressure before and during MCAO in rats whose cortical surface was superfused with vehicle or drug via a cranial window starting at 15 min of MCAO
| Treatment |
MCAO Duration, min |
|||
|---|---|---|---|---|
| Baseline | 30 | 90 | 120 | |
| No superfusion | 99±2 | 100±1 | 101±1 | 99±1 |
| CSF superfusion | 101±1 | 101±1 | 99±1 | 99±1 |
| 0.1% ethanol superfusion | 107±3 | 108±2 | 109±3 | 108±3 |
| HET0016 superfusion | 100±1 | 101±1 | 100±1 | 100±1 |
| 0.1% ethanol superfusion/Hb transfusion | 100±1 | 101±2 | 103±2 | 101±2 |
| HET0016 superfusion/Hb transfusion | 100±1 | 100±1 | 110±7 | 101±3 |
| 0.02% DMSO superfusion | 103±2 | 101±1 | 101±1 | 101±1 |
| BQ610 superfusion | 101±1 | 101±1 | 100±1 | 101±1 |
| BQ610 superfusion/Hb transfusion | 101±1 | 101±1 | 101±1 | 103±1 |
Values are means ± SE. MCAO, middle cerebral artery occlusion; CSF, cerebrospinal fluid. Some groups of rats also underwent hemoglobin (Hb) exchange transfusion at 35–50 min.