Table 2.
Arterial Po2, Pco2, and pH at baseline and at 120 min of MCAO in rats whose brains were superfused with vehicle or drug via a cranial window starting at 15 min of MCAO
| Treatment |
Po2, Torr |
Pco2, Torr
|
pH
|
|||
|---|---|---|---|---|---|---|
| Baseline | 120 min | Baseline | 120 min | Baseline | 120 min | |
| No superfusion | 137±9 | 156±8 | 39±1 | 37±1 | 7.39±0.01 | 7.40±0.01 |
| CSF superfusion | 142±10 | 156±7 | 37±1 | 38±1 | 7.42±0.01 | 7.41±0.01 |
| 0.1% ethanol superfusion | 141±10 | 158±5 | 39±1 | 39±1 | 7.42±0.01 | 7.43±0.01 |
| HET0016 superfusion | 135±6 | 161±11 | 39±1 | 38±1 | 7.39±0.01 | 7.41±0.01 |
| 0.1% ethanol superfusion/Hb transfusion | 132±7 | 144±12 | 40±1 | 39±2 | 7.38±0.01 | 7.35±0.03 |
| HET0016 superfusion/Hb transfusion | 138±12 | 128±11 | 40±2 | 38±1 | 7.38±0.01 | 7.37±0.01 |
| 0.02% DMSO superfusion | 144±13 | 123±15 | 41±1 | 41±1 | 7.39±0.01 | 7.39±0.01 |
| BQ610 superfusion | 162±10 | 146±8 | 38±1 | 41±1 | 7.40±0.01 | 7.38±0.01 |
| BQ610 superfusion/Hb transfusion | 149±7 | 155±12 | 41±1 | 41±1 | 7.40±0.01 | 7.39±0.01 |
Values are means ± SE. Some groups of rats also underwent Hb exchange transfusion at 35–50 min.