Fig. 3.

Changes in mean arterial pressure (ΔMAP) (A) and heart rate (ΔHR) (B) from baseline values in mice in response to the intracerebroventricular (ICV) infusion of 0.225 M NaCl in artificial cerebrospinal fluid (aCSF-HiNa) at 0.4 μl/min for 60 min. α₂ +/− = mice heterozygous for the α₂ Na⁺-K⁺-ATPase gene knockout; +/+ = wild-type mice. Values represent means ± SE of ΔMAP or ΔHR (MAP or HR averaged over 5-min intervals minus baseline) during the 60-min infusion. Baseline blood pressures (male +/+: 123 ± 2 mmHg; male α₂ +/−: 122 ± 2 mmHg; female +/+: 118 ± 3 mmHg; female α₂ +/−: 118 ± 2 mmHg) and heart rates (male +/+: 500 ± 24 beats/min; male α₂ +/−: 507 ± 13 beats/min; female +/+: 483 ± 20 beats/min; female α₂ +/−: 557 ± 18 beats/min) were recorded over a 10-min interval immediately preceding the start of aCSF-HiNa. *P < 0.05 vs. female +/+.