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Changes from baseline in MAP or HR following the ICV infusion of ANG II (150 ng/min). Baseline MAP and HR values were averaged over the 10-min period immediately preceding each ANG II infusion, and this value was subtracted from the absolute MAP and HR at each time point to calculate ΔMAP or ΔHR. Baseline MAP before ICV infusions was: α2 +/− = 113 ± 5, +/+ = 113 ± 4 mmHg; HR: α2 +/− = 455 ± 33, +/+ = 474 ± 29 beats/min.
