Table 3.
Influence of SLC6A3 and COMT genotypes on neural activation in regions of interest during inhibition
| MNI coordinates |
||||||||
|---|---|---|---|---|---|---|---|---|
| Region | Side | x | y | z | t | Pcorr | voxels | |
| Genotype | Contrast | |||||||
| SLC6A3 | StopInhibit—Go | |||||||
|
|
||||||||
| STN | R | 10 | −12 | −8 | 2.86 | 0.031 | 6 | |
| SMA | R | 8 | −20 | 72 | 4.46 | 0.003 | 450 | |
|
| ||||||||
| COMT | StopInhibit—Go | |||||||
|
|
||||||||
| IFG (pars opercularis) | R | 56 | 14 | 26 | 4.34 | 0.000 | 781 | |
|
| ||||||||
| COMT | Go—Fixation | |||||||
|
|
||||||||
| IFG (pars opercularis) | R | 48 | 10 | 0 | 5.17 | 0.000 | 977 | |
| STN | R | 12 | −10 | −2 | 4.18 | 0.020 | 23 | |
| Pre-SMA | R | 4 | 6 | 48 | 6.88 | 0.000 | 1,315 | |
| Globus pallidus | R | 16 | 4 | −2 | 2.93 | 0.026 | 18 | |
|
| ||||||||
| COMT | StopInhibit—Fixation | |||||||
|
|
||||||||
| IFG (pars opercularis) | R | 38 | 8 | 14 | 5.08 | 0.000 | 1,783 | |
| STN | R | 12 | −16 | −4 | 3.93 | 0.019 | 23 | |
| Pre-SMA | R | 8 | 6 | 46 | 6.51 | 0.000 | 1,297 | |
| Globus pallidus | R | 16 | 4 | −2 | 4.69 | 0.025 | 21 | |
Note. Region of interest analyses surviving a p < 0.05 small-volume correction. x, y, and z coordinates are shown in MNI space. MNI, Montreal Neurological Institute; Pcorr, corrected cluster-level p-value; IFG, inferior frontal gyrus; STN, subthalamic nucleus; SMA, supplementary motor area; R, right; N =42.