Table 4.
Genotype group differences in neural activation during inhibition
| Genotype | Contrast | Group (N) | ||
|---|---|---|---|---|
| Region | Mean Percent Signal Change (SEM) | |||
| SLC6A3 | StopInhibit—Go | 10/10 (26) | 9+ (16) | |
| IFG | 0.064 (0.014) | 0.074 (0.016) | ||
| STN | 0.021 (0.012) | 0.057 (0.020) | ||
| SMA | 0.004 (0.011) | 0.043 (0.012) | ||
| GP | 0.047 (0.015) | 0.082 (0.028) | ||
|
| ||||
| COMT | StopInhibit—Go | v/v (10) | v/m (26) | m/m (6) |
| IFG | 0.073 (0.026) | 0.074 (0.011) | 0.034 (0.033) | |
| STN | 0.034 (0.025) | 0.044 (0.014) | -0.002 (0.021) | |
| SMA | 0.027 (0.015) | 0.022 (0.012) | -0.007 (0.021) | |
| GP | 0.057 (0.00) | 0.063 (0.000) | 0.054 (0.000) | |
|
| ||||
| COMT | Go—Fixation | v/v (10) | v/m (26) | m/m (6) |
| IFG | -0.021 (0.043) | 0.044 (0.016) | 0.061 (0.053) | |
| STN | 0.025 (0.035) | 0.042 (0.017) | 0.074 (0.032) | |
| SMA | 0.049 (0.039) | 0.110 (0.015) | 0.102 (0.017) | |
| GP | 0.002 (0.052) | 0.058 (0.020) | 0.096 (0.033) | |
|
| ||||
| COMT | StopInhibit—Fixation | v/v (10) | v/m (26) | m/m (6) |
| IFG | 0.052 (0.029) | 0.118 (0.016) | 0.094 (0.085) | |
| STN | 0.059 (0.031) | 0.086 (0.020) | 0.072 (0.042) | |
| SMA | 0.076 (0.033) | 0.132 (0.016) | 0.095 (0.035) | |
| GP | 0.059 (0.036) | 0.121 (0.022) | 0.149 (0.044) | |
Note. Region of interest analyses thresholded at p < 0.01 uncorrected voxel level and percent signal change extracted. IFG, inferior frontal gyrus; STN, subthalamic nucleus; SMA, supplementary motor area; GP, globus pallidus; N =42.