Table 5.

Gene combinations

Study	Gene polymorphism combinations	Significant association with AKI	Magnitude of association	Significance of association
Wattanathum 2005	IL-10 −592 C/A, +734 A/G and + 3367 G/A	Yes		P = 0.024
Stafford-Smith 2005	eNOS + 894 G/T and AGTR1 + 1166 A/C	No		P = 0.006a,c
	IL-6 −572 G/C and TNF-α −308 G/A	No		P = 0.05a,c
	AGT + 842 T/C and IL-6 −572 G/C	Yes		P ≤ 0.0001c
	APO E e4 and AGT + 842 T/C	No		P = 0.03a,c
	AGTR1 + 1166 A/C and APO E e4	No		P = 0.02a,c
	eNOS + 894 G/T and ACE I/D	No		P = 0.006a,d
	AGT + 842 T/C and APO E e2	No		P = 0.03a,d
Jaber 2004	IL-10 −1082 G/A and TNF-α −308 G/A	Yes	HR = 5.72	P = 0.004
Treszl 2002	TNF-α −308 G/A and IL-6 −174 G/C	Yes	OR = 6.07b	P < 0.01
	TNF-α −308 G/A and IL-1b + 3954 C/T	No		NS
	TNF-α −308 G/A and IL-10 −1082 G/A	No		NS
	IL-1b + 3954 C/T and IL-6 −174 G/C	No		NS
	IL-1b + 3954 C/T and IL-10 −1082 G/A	No		NS
	IL-10 −1082 G/A and IL-6 −174 G/C	No		NS

^aNot significant after adjustment for multiple comparisons;

^bcalculated from published data;

^cfor Caucasian subgroup;

^dfor African-American subgroup.

Italics represent results of multivariable analysis.