Table 4.
Summary of treatment effects of early invasive versus conservative therapy in patients with CKD and non–ST elevation ACS overall and according to CKD classa
| Outcome | All-Cause Mortality (RR [95% CI]) | Nonfatal MI (RR [95% CI]) | Death or Nonfatal MI (RR [95% CI]) | Rehospitalization (RR [95% CI]) |
|---|---|---|---|---|
| Overall, stages 3 to 5 CKD | ||||
| in-hospital | 0.77 (0.42 to 1.44) | 1.06 (0.51 to 2.20) | 1.00 (0.64 to 1.56) | NA |
| 1 yr | 0.76 (0.49 to 1.17) | 0.78 (0.52 to 1.16) | 0.79 (0.53 to 1.18) | 0.76 (0.66 to 0.87) |
| Stage 3 CKD | ||||
| in-hospital | 0.89 (0.45 to 1.76) | 0.95 (0.41 to 2.22) | 0.88 (0.43 to 1.79) | NA |
| 1 yr | 0.75 (0.41 to 1.37) | 0.72 (0.47 to 1.11) | 0.76 (0.45 to 1.27) | 0.72 (0.62 to 0.84) |
| Stage 3a CKD (GFR 45 to 59 ml/min per 1.73 m2) | ||||
| in-hospital | 1.07 (0.45 to 2.58)b | 0.90 (0.38 to 2.12) | 0.97 (0.45 to 2.05) | NA |
| 1 yr | 0.75 (0.40 to 1.40) | 0.72 (0.47 to 1.10) | 0.84 (0.50 to 1.42) | 0.73 (0.62 to 0.86) |
| Stage 3b CKD (GFR 30 to 44 ml/min per 1.73 m2) | ||||
| in-hospital | 0.69 (0.24 to 1.97) | 0.52 (0.18 to 1.54)b | 0.63 (0.30 to 1.35) | NA |
| 1 yr | 0.63 (0.30 to 1.32) | 0.58 (0.24 to 1.42) | 0.57 (0.32 to 1.00) | 0.85 (0.51 to 1.41) |
| Stages 4 to 5 CKD (GFR <30 ml/min per 1.73 m2) | ||||
| in-hospital | 0.41 (0.11 to 1.55)b | 1.37 (0.58 to 3.24)c | 0.94 (0.47 to 1.90)c | NA |
| 1 yr | 0.78 (0.33 to 1.82) | 1.11 (0.49 to 2.52) | 0.94 (0.55 to 1.60) | 1.01 (0.70 to 1.46) |
a
Only cardiovascular hospitalizations were recorded in the ICTUS trial. CI, confidence interval; RR, relative risk.
Because of low number of events, based on
b
four or
c
three trials only.