Table 4.
Single SNP association analyses of SNPs 1–8 in 394 cases and 394 controlsa
| SNP | Genotype | OR (95% CI)b | Global Pc | Corrected Pd |
|---|---|---|---|---|
| SNP 1 | GG | 1.46 (0.91–2.35) | 6.0 × 10−5 | 4.8 × 10−4 |
| (rs943887) | AG | 0.96 (0.59–1.56) | ||
| AA | Reference | |||
| SNP 2 | TT | 1.60 (1.09–2.36) | 0.0002 | 0.0017 |
| (rs943888) | CT | 1.24 (0.88–1.75) | ||
| CC | Reference | |||
| SNP 3 | GG | 1.66 (1.08–2.53) | 0.0061 | 0.0476 |
| (rs56131962) | AG | 1.27 (0.84–1.92) | ||
| AA | Reference | |||
| SNP 4 | CC | 1.72 (1.12–2.64) | 0.0036 | 0.0284 |
| (rs55766725) | CT | 1.29 (0.85–1.96) | ||
| TT | Reference | |||
| SNP 5 | GG | 1.61 (1.06–2.45) | 0.0064 | 0.0499 |
| (rs1263648) | AG | 1.22 (0.81–1.82) | ||
| AA | Reference | |||
| SNP 6 | AA | 1.58 (1.04–2.39) | 0.0080 | 0.0623 |
| (rs1263649) | AG | 1.20 (0.80–1.79) | ||
| GG | Reference | |||
| SNP 7 | GG | 1.07 (0.63–1.80) | 0.1028 | 0.5803 |
| (rs1263650) | AG | 0.97 (0.57–1.66) | ||
| AA | Reference | |||
| SNP 8 | TT | 1.20 (0.72–2.01) | 0.0668 | 0.4249 |
| (rs1263651) | CT | 1.03 (0.61–1.74) | ||
| CC | Reference |
a
Data for single nucleotide polymorphisms (SNPs) 1 and 2 were missing in eight individuals, and SNP 3–8 data were missing in three individuals in the patient group. No missing data in the control group.
b
Odds ratio (OR) values after adjusting for age and gender by logistic regression.
c
Adjusting for age and gender by logistic regression, calculated by the likelihood ratio chi-square test (using genotype data) which compares the model with the marker and the model without the marker.
d
After Bonferroni correction for multiple testing.