Table 5.
Haplotype association analysis in 394 cases and 394 controlsa
| Haplotype | Haplotype Count (Frequency)
|
OR (95% CI)b | P for ORc | Global Pd | |
|---|---|---|---|---|---|
| Case | Control | ||||
| Block 1 | |||||
| GT (haplotype 1) | 412 (0.52) | 372 (0.47) | 1.41 (1.12–1.77) | 0.0033 | 7.3 × 10−5 |
| AC (haplotype 2) | 208 (0.26) | 265 (0.33) | Reference | — | |
| GC | 154 (0.19) | 159 (0.20) | 1.23 (0.93–1.64) | 0.1503 | |
| Block 2 | |||||
| GCGAGT (haplotype 3) | 478 (0.60) | 443 (0.56) | 1.18 (0.92–1.51) | 0.1849 | 0.0280 |
| ATAGAC (haplotype 4) | 172 (0.22) | 188 (0.24) | Reference | — | |
| ATAGGT | 40 (0.05) | 62 (0.08) | 0.71 (0.45–1.10) | 0.1265 | |
| ATAGGC | 34 (0.04) | 47 (0.06) | 0.79 (0.49–1.29) | 0.3449 | |
| ATAGAT | 26 (0.03) | 31 (0.04) | 0.92 (0.52–1.61) | 0.7612 | |
| Others | 42 (0.05) | 27 (0.03) | 1.70 (1.00–2.88) | 0.0479 | |
a
Haplotypes with frequencies ≥ 3%.
b
Odds ratio (OR) calculated by logistic regression.
c
By Wald χ2 test in logistic regression.
d
For likelihood ratio chi-square test (using haplotype data).