Figure 2.

iNKT deficiency results in more significant alterations in renal function after anti-GBM serum administration. C57BL/6J WT and Jα18^−/− mice were injected with anti-GBM serum, and control mice were injected with PBS. Urine and blood were collected at selected time points to assess renal function. C57BL/6J Jα18^−/− mice, which lack iNKT lymphocytes, had higher levels of proteinuria on days 7 and 12 (A) and a higher BUN level on day 14 (B) compared with C57BL/6 WT mice. Results are expressed as mean ± SEM (n = 5). *P < 0.05 versus control; #P < 0.05 versus WT. This is representative of three isolated experiments.