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CKD effect on NH lesion development persists in OPN-deficient mice. (A) Serum levels of OPN were measured in CKD (n = 10) and sham (n = 8) animals. CKD animals had a significantly higher OPN level than that of the sham animals (**P < 0.05). (B) Six weeks after CKD creation and 3 wk after AV fistula creation, there was no significant difference between the OPN-/- and OPN+/+ mice in anastomotic NH lesion size. NS.
