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Effect of WNK3 isoforms versus WNK4. (A) 22Na+ flux in oocytes injected with NCCT and either WNK3 (R, renal; B, brain) or WNK4 as indicated. Significant differences from NCCT alone are indicated. *P < 0.001. (B) ECFP-NCCT fluorescence signal from oocytes injected as in A. Significant differences are indicated. *P < 0.001; **P < 0.05. (C) Representative confocal microscopy images for each injection condition in B. HCTZ, hydrochlorothiazide.
