Table 2.
Physiological parameters after 4-wk tempol treatment
| Parameter | KK/Ta-WT
|
KK/Ta-Akita
|
||
|---|---|---|---|---|
| Vehicle | Tempol | Vehicle | Tempol | |
| Body weight (g) | 30.1 ± 0.5 | 31.2 ± 0.9 | 23.1 ± 0.9 | 21.6 ± 0.7 |
| Systolic blood pressure (mmHg) | 113 ± 4 | 116 ± 2 | 122 ± 3 | 117 ± 5 |
| Blood glucose (mg/dl) | 100 ± 19 | 100 ± 4 | 519 ± 34 | 486 ± 29 |
| HbA1c (%) | 3.7 ± 0.1 | 3.7 ± 0.1 | 12.3 ± 0.4 | 11.5 ± 0.2 |
| Plasma creatinine (mg/dl) | 0.135 ± 0.003 | 0.149 ± 0.022 | 0.165 ± 0.014 | 0.176 ± 0.014 |
| BUN (mg/dl) | 23.0 ± 1.4 | 22.2 ± 1.0 | 44.1 ± 4.1 | 42.0 ± 5.8 |
| Total cholesterol (mg/dl) | 87.7 ± 6.6 | 83.7 ± 6.2 | 147.4 ± 10.4 | 139.8 ± 15.5 |
| Trigriceride (mg/dl) | 202.4 ± 10.5 | 195.9 ± 12.3 | 202.8 ± 10.6 | 112.0 ± 17.9a |
Values are means ± SEM. n = 6 per group; n = 4 per group for plasma creatinine.
a
P < 0.01 versus KK/Ta-Akita vehicle.