Table 1. Anthropometrics and quantitative metabolic traits in 4,239 successfully genotyped individuals with normal glucose tolerance from the population-based Inter99 study sample in relation to the rs2237895 genotypes of KCNQ1.
| rs2237895 | ||||
| AA | AC | CC | Padditive | |
| N (m/w) | 1,489 (689/800) | 2,073 (972/1101) | 677 (308/369) | |
| Age (years) | 45±8 | 45±8 | 46±8 | |
| BMI (kg/m2) | 25.6±4.0 | 25.5±4.1 | 25.5±4.2 | 0.45 |
| HOMA-IR | 9.0±5.8 | 8.9±5.7 | 8.7±5.3 | 0.25 |
| Glucose traits | ||||
| Fasting p-glucose (mmol/l) | 5.3±0.4 | 5.3±0.4 | 5.3±0.4 | 0.31 |
| p-glucose at 30 min (mmol/l) | 8.2±1.6 | 8.2±1.5 | 8.2±1.5 | 0.78 |
| p-glucose at 120 min (mmol/l) | 5.5±1.1 | 5.5±1.1 | 5.5±1.1 | 0.79 |
| incAUC glucose | 181±103 | 180±99 | 185±101 | 0.62 |
| Insulin traits | ||||
| Fasting s-insulin (pmol/l) | 38±24 | 37±24 | 37±22 | 0.31 |
| s-insulin at 30 min (pmol/l) | 299±200 | 280±164 | 277±160 | 0.0076 |
| s-insulin at 120 min (pmol/l) | 172±136 | 165±126 | 166±135 | 0.38 |
| incAUC insulin | 21,810±14,685 | 20,503±12,386 | 20,477±12,491 | 0.015 |
| Fasting s-C-peptide (pmol/l) | 537±201 | 540±224 | 535±208 | 0.89 |
| C-peptide at 30 min (pmol/l) | 2,014±704 | 1,957±681 | 1,950±702 | 0.022 |
| C-peptide at 120 min (pmol/l) | 2,064±788 | 2,051±795 | 2,048±811 | 0.42 |
| incAUC C-peptide (pmol/l) | 157,265±53,026 | 153,022±51,967 | 152,965±53,118 | 0.045 |
| Insulinogenic index | 32±22 | 30±19 | 30±17 | 0.0065 |
| Disposition index | 4.3±3.1 | 4.1±2.9 | 4.1±2.7 | 0.069 |
| BIGTT-SI | 10±4 | 10±4 | 11±4 | 0.051 |
| BIGTT-AIR | 1,950±1,179 | 1,875±964 | 1,846±951 | 0.04 |
The table includes unadjusted mean±S.D data. P-values shown are for an additive genetic model and are adjusted for age, BMI and sex. incAUC, incremental area under the curve; HOMA-IR, homeostasis model assessment of insulin resistance; BIGTT-SI, BIGTT-insulin sensitivity; BIGTT-AIR, BIGTT acute insulin response.