Table 2. Anthropometrics and quantitative metabolic traits of a total of 5,597 successfully genotyped middle-aged and treatment-naïve individuals from the Inter99 sample including the 4,239 glucose-tolerant individuals presented in Table 1.
| rs2237895 | |||||
| AA | AC | CC | Padditive | ||
| N (m/w) | 1,933 (940/993) | 2,721 (1,373/1,348) | 943 (480/463) | ||
| Age (years) | 46±8 | 46±8 | 47±8 | ||
| BMI (kg/m2) | 26.2±4.5 | 26.2±4.5 | 26.4±4.8 | 0.66 | |
| HOMA-IR | 10.5±7.6 | 10.5±8.1 | 10.9±8.5 | 0.75 | |
| Glucose traits | |||||
| Fasting p-glucose (mmol/l) | 5.5±0.8 | 5.5±0.7 | 5.6±0.9 | 0.068 | |
| p-glucose at 30 min (mmol/l) | 8.7±1.9 | 8.7±1.8 | 8.9±2.0 | 0.30 | |
| p-glucose at 120 min (mmol/l) | 6.1±2.0 | 6.2±2.1 | 6.3±2.2 | 0.18 | |
| incAUCglucose | 219±134 | 220±135 | 228±136 | 0.46 | |
| Insulin traits | |||||
| Fasting s-insulin (pmol/l) | 42±27 | 42±28 | 42±28 | 0.50 | |
| s-insulin at 30 min (pmol/l) | 302±198 | 286±179 | 284±169 | 0.0011 | |
| s-insulin at 120 min (pmol/l) | 219±217 | 215±208 | 218±217 | 0.68 | |
| incAUC insulin | 23,743±16,727 | 22,500±15,554 | 22,604±15,572 | 0.0061 | |
| Fasting s-C-peptide (pmol/l) | 588±255 | 597±283 | 607±286 | 0.46 | |
| C-peptide at 30 min (pmol/l) | 2,032±713 | 1,984±722 | 1,983±716 | 0.013 | |
| C-peptide at 120 min (pmol/l) | 2,304±1,003 | 2,307±1,030 | 2,320±1,012 | 0.84 | |
| incAUC C-peptide | 163,740±57,671 | 160,006±57,933 | 159,661±58,165 | 0.035 | |
| Insulinogenic index | 30.7±21.3 | 28.8±19.0 | 28.1±17.5 | 0.00073 | |
| Disposition index | 3.8±3.0 | 3.6±2.8 | 3.5±2.6 | 0.0097 | |
| BIGTT-SI | 9.2±4.0 | 9.3±4.1 | 9.1±4.2 | 0.55 | |
| BIGTT-AIR | 1,892±1,140 | 1,841±1,062 | 1,784±948 | 0.0083 | |
Study participants are stratified according to rs2237895 genotypes of KCNQ1.
P-values shown are for an additive genetic model and are adjusted for age, BMI and sex. incAUC, incremental area under the curve; HOMA-IR, homeostasis model assessment of insulin resistance; BIGTT-SI, BIGTT-insulin sensitivity; BIGTT-AIR, BIGTT acute insulin response.