Table 3. Polysomnographic Sleep Measures during Baseline, SR1 and SR5 for PER34/4, PER34/5 and PER35/5 Subjects (Mean±SD).
| Sleep Measure | Baseline Night | Sleep Restriction Night 1 (SR1) | Sleep Restriction Night 5 (SR5) | |||||||||
| PER34/4 | PER34/5 | PER35/5 | p* | PER34/4 | PER34/5 | PER35/5 | p* | PER34/4 | PER34/5 | PER35/5 | p* | |
| Total sleep time (min) | 513.90±54.69 | 513.42±59.34 | 521.04±45.63 | 0.904 | 224.45±9.67 | 226.62±8.93 | 226.93±7.16 | 0.421 | 233.11±5.10 | 231.45±8.87 | 234.12±4.05 | 0.319 |
| Sleep efficiency (%) | 85.71±9.10 | 86.08±9.77 | 88.42±7.95 | 0.646 | 93.69±4.02 | 94.48±3.72 | 94.82±2.62 | 0.455 | 97.13±2.13 | 96.35±3.72 | 95.58±1.71 | 0.245 |
| Latency to sleep onset (min) | 15.81±22.75 | 21.75±18.82 | 9.65±8.42 | 0.088 | 3.71±5.27 | 3.43±4.20 | 3.11±2.99 | 0.894 | 1.65±3.19 | 2.52±3.64 | 1.81±3.11 | 0.399 |
| Latency to REM sleep (min) | 73.76±37.21 | 77.71±36.07 | 67.85±32.60 | 0.645 | 50.51±29.52 | 55.31±29.74 | 58.89±26.71 | 0.556 | 40.55±26.13 | 42.50±28.78 | 45.62±19.30 | 0.817 |
| WASO (min) | 58.24±52.83 | 56.32±54.11 | 53.92±44.69 | 0.961 | 7.29±8.97 | 5.90±7.27 | 5.86±5.64 | 0.640 | 2.79±2.70 | 3.57±5.56 | 2.77±3.61 | 0.619 |
| Stage 1 duration (min) | 54.59±23.47 | 51.74±28.25 | 58.38±36.28 | 0.699 | 14.63±7.83 | 15.26±11.28 | 13.64±8.83 | 0.846 | 8.98±5.57 | 8.72±6.10 | 9.42±7.56 | 0.925 |
| Stage 1 (%TST) | 10.63±4.50 | 10.17±5.44 | 11.26±6.86 | 0.770 | 6.58±3.65 | 6.84±5.06 | 6.06±4.02 | 0.838 | 3.86±2.43 | 3.81±2.74 | 4.03±3.21 | 0.964 |
| Stage 2 duration (min) | 272.02±45.24 | 277.42±56.41 | 278.42±50.79 | 0.846 | 99.82±29.32 | 99.19±27.78 | 103.43±34.88 | 0.890 | 102.38±27.65 | 97.49±33.34 | 90.46±33.07 | 0.426 |
| Stage 2 (%TST) | 53.09±7.58 | 54.02±9.02 | 53.55±8.89 | 0.856 | 44.50±13.08 | 43.87±12.42 | 45.96±15.77 | 0.868 | 43.94±11.85 | 42.26±14.63 | 38.76±14.55 | 0.454 |
| Stage 3 duration (min) | 41.85±16.54 | 39.02±18.84 | 46.42±21.15 | 0.384 | 28.96±11.24 | 32.94±15.36 | 34.11±13.53 | 0.245 | 33.39±14.21 | 31.05±14.77 | 38.65±17.93 | 0.242 |
| Stage 3 (%TST) | 8.21±3.41 | 7.66±3.73 | 8.88±3.80 | 0.489 | 12.88±5.01 | 14.54±6.70 | 14.98±5.90 | 0.286 | 14.33±6.13 | 13.38±6.34 | 16.51±7.60 | 0.272 |
| Stage 4 duration (min) | 25.33±25.02 | 28.41±27.87 | 21.27±26.67 | 0.644 | 30.00±24.74 | 28.26±27.50 | 31.50±32.67 | 0.903 | 30.24±25.54 | 35.19±29.74 | 40.38±39.29 | 0.464 |
| Stage 4 (%TST) | 4.78±4.64 | 5.62±5.66 | 3.91±4.75 | 0.488 | 13.34±10.91 | 12.39±11.94 | 13.73±14.08 | 0.889 | 12.94±10.89 | 15.10±12.70 | 17.12±16.63 | 0.474 |
| SWS duration (min) | 67.18±35.14 | 67.43±38.08 | 67.69±44.17 | 0.999 | 58.96±27.81 | 61.20±30.23 | 65.61±32.70 | 0.752 | 63.63±28.30 | 66.25±30.95 | 79.04±37.44 | 0.272 |
| SWS (%TST) | 12.98±6.52 | 13.28±7.65 | 12.79±7.68 | 0.966 | 26.22±12.33 | 26.93±13.05 | 28.71±14.05 | 0.815 | 27.26±12.07 | 28.47±13.13 | 33.62±15.72 | 0.292 |
| REM duration (min) | 120.09±30.31 | 116.79±30.64 | 116.54±20.30 | 0.836 | 51.00±15.68 | 50.90±15.91 | 44.32±15.73 | 0.341 | 58.03±17.13 | 57.82±15.25 | 55.96±17.35 | 0.918 |
| REM sleep (%TST) | 23.30±5.03 | 22.52±4.64 | 22.40±3.63 | 0.669 | 22.67±6.75 | 22.40±6.77 | 19.51±6.79 | 0.290 | 24.89±7.32 | 24.95±6.44 | 23.58±7.39 | 0.806 |
*
p values are for the comparison of the three genotypes. At baseline, PER34/4 (n = 47), PER34/5 (n = 57), and PER35/5 (n = 13); at SR1, PER34/4 (n = 49), PER34/5 (n = 54), and PER35/5 (n = 14); at SR5, PER34/4 (n = 51), PER34/5 (n = 57) and PER35/5 (n = 13).
Abbreviations: Total Sleep Time (TST); Wake After Sleep Onset (WASO); Slow-Wave Sleep (SWS); Rapid Eye Movement (REM).