Table 2. Summary of the association results for rs2269577 in three independent samples as well as the combined sample.
| Number | Allele (Frequency ) | Genotype (Frequency) | P_allele | P_trend | OR (95% CI) | |||||
| C | G | C/C | C/G | G/G | ||||||
| Initial Sequence Analysis | Cases | 319 | 264 (0.41) | 374 (0.59) | 57 (0.18) | 150 (0.47) | 112 (0.35) | 0.005 | 0.007 | 1.36 (1.09–1.71) |
| Controls | 294 | 198 (0.34) | 390 (0.66) | 41 (0.14) | 116 (0.39) | 137 (0.47) | ||||
| Follow-up By Sequencing | Cases | 365 | 298 (0.41) | 432 (0.59) | 81 (0.22) | 136 (0.37) | 148 (0.41) | 0.005 | 0.008 | 1.31 (1.07–1.59) |
| Controls | 404 | 274 (0.34) | 534 (0.66) | 45 (0.11) | 184 (0.46) | 175 (0.43) | ||||
| Follow-up By TaqMan | Cases | 1402 | 1195 (0.43) | 1609 (0.47) | 271 (0.19) | 653 (0.47) | 478 (0.34) | 0.002 | 0.003 | 1.18 (1.06–1.32) |
| Controls | 1288 | 993 (0.39) | 1583 (0.62) | 187 (0.15) | 619 (0.48) | 482 (0.37) | ||||
| Combined Analysis | Cases | 2086 | 1757 (0.42) | 2415 (0.58) | 409 (0.20) | 939 (0.45) | 738 (0.35) | 2.01×10−6 | 2.94×10−6 | 1.23 (1.13–1.35) |
| Controls | 1986 | 1465 (0.37) | 2507 (0.63) | 273 (0.14) | 919 (0.46) | 794 (0.40) | ||||
OR: per allele odds ratio from trend test.