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Concept of temperature-responsive ion-exchange chromatography: (a) electrostatic interaction with analyte and (b) chromatograms ((i) 10°C and (ii) 50°C) of adenosine nucleotides separated on cationic copolymer-grafted silica beads. Peaks: 1, AMP; 2, ADP; 3, ATP. Adapted from Nagase et al. (2008b). Copyright 2008, American Chemical Society.
